Methotrexate Induced Pancytopenia

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Methotrexate Induced Pancytopenia

The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become proble...

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Methotrexate-induced pancytopenia in a patient with ectopic pregnancy

Corresponding author: Edward Chia-Cheng Lai PhD School of Pharmacy Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University No. 1, University Road Tainan 701, Taiwan Phone: +886-6-2353535 E-mail: tb8991010@mail. ncku.edu.tw 1 Department of Pharmacy, Chang Gung Memorial Hospital, Keelung, Taiwan 2 School of Pharmacy, Institute of Clinical Phar...

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Leukemoid reaction after methotrexate-induced pancytopenia in a patient undergoing continuous ambulatory peritoneal dialysis.

Methotrexate has been used as an important alternative therapy in the treatment of various rheumatic diseases. Life threatening marrow suppression in end-stage renal disease patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis has been reported. A 33-year-old woman with systemic lupus erythematosus undergoing chronic peritoneal dialysis developed severe mucositis and pa...

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Methotrexate-induced nonhealing cutaneous ulcers in a nonpsoriatic patient without pancytopenia

Methotrexate forms one of the main drugs in the pharmacological management of rheumatoid arthritis, psoriasis, and some neoplastic diseases. Methotrexate rarely causes cutaneous ulceration and most cases are reported in patients with psoriasis and have been accompanied by pancytopenia. The author here reports occurrence of multiple (two) cutaneous ulcers due to methotrexate in a nonpsoriatic pa...

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Levetiracetam-induced pancytopenia

Pancytopenia is a rare side effect of levetiracetam (LEV) that is associated with severe morbidity that requires hospitalization. Here, we report a patient with a right temporoparietal tumor who underwent a temporal craniotomy with resection of the mass and was started on LEV for seizure prophylaxis per the neurosurgery local protocol. The patient developed LEV-induced pancytopenia, which was s...

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ژورنال

عنوان ژورنال: Case Reports in Rheumatology

سال: 2014

ISSN: 2090-6889,2090-6897

DOI: 10.1155/2014/679580